About BioSpring

What is BioSpring?

Background and Purpose

BioSpring bridges molecular visualization with real-time physics-based multi-scale simulation, enabling researchers to model complex biological systems interactively and efficiently.

Applications

  • Protein dynamics and conformational analysis
  • Protein-DNA docking and membrane interactions
  • Real-time exploration for hypothesis testing
  • Integrative modeling under experimental constraints

Pictures

Technical Approach

  • Elastic Network Model with multi-resolution support
  • Interactive tools such as haptic feedback (optional) for user guidance
  • Multi-platform support with integration into immersive environments (VR, etc.)

Team and Collaborations

  • BioSpring originated around 2007 and its first developers were Olivier Delalande, Nicolas Férey and Benoist Laurent, who were later joined by Alex Tek
  • Olivier Delalande’s team in particular developed numerous applications for linking to experimental data, with the participation of Anne-Elisabeth Molza and Dominique Mias-Lucquin, among others
  • Sébastien Doutreligne, Xavier Martinez, André Lanrezac and Joao Rodriguez were involved in further connected developments related to UnityMol, MDDriver, UNILIPID and later MolPlay

Learn how to use BioSpring