¶What is BioSpring?
¶Background and Purpose
BioSpring bridges molecular visualization with real-time physics-based multi-scale simulation, enabling researchers to model complex biological systems interactively and efficiently.
¶Applications
- Protein dynamics and conformational analysis
- Protein-DNA docking and membrane interactions
- Real-time exploration for hypothesis testing
- Integrative modeling under experimental constraints
¶Pictures
¶Technical Approach
- Elastic Network Model with multi-resolution support
- Interactive tools such as haptic feedback (optional) for user guidance
- Multi-platform support with integration into immersive environments (VR, etc.)
¶Team and Collaborations
- BioSpring originated around 2007 and its first developers were Olivier Delalande, Nicolas Férey and Benoist Laurent, who were later joined by Alex Tek
- Olivier Delalande’s team in particular developed numerous applications for linking to experimental data, with the participation of Anne-Elisabeth Molza and Dominique Mias-Lucquin, among others
- Sébastien Doutreligne, Xavier Martinez, André Lanrezac and Joao Rodriguez were involved in further connected developments related to UnityMol, MDDriver, UNILIPID and later MolPlay